| Mode: | Basketball |
| Year: | 1980–81 |
| Team: | Penn Quakers |
| Conference: | Ivy League |
| Short Conf: | Ivy |
| Record: | 20–8 |
| Conf Record: | 13–1 |
| Hc Year: | 4th |
| Bowl Result: | First Round |
The 1980–81 Penn Quakers men's basketball team represented the University of Pennsylvania during the 1980–81 NCAA Division I men's basketball season. The Quakers, coached by Bob Weinhauer, played in the Ivy League and had a 20-8 win–loss record.
|-!colspan=9 style=| Ivy League tournament|-!colspan=9 style=|National Invitation Tournament[1]