| Mode: | Basketball |
| Year: | 1980–81 |
| Prev Year: | 1979–80 |
| Next Year: | 1981–82 |
| Team: | Ole Miss Rebels |
| Conference: | Southeastern Conference |
| Short Conf: | SEC |
| Record: | 16–14 |
| Conf Record: | 8–10 |
| Hc Year: | 5th |
| Champion: | SEC tournament champions |
| Bowl Result: | First Round |
The 1980–81 Ole Miss Rebels men's basketball team represented the University of Mississippi in the 1980–81 NCAA Division I men's basketball season. The Rebels were led by fifth-year head coach, Bob Weltlich. The Rebels played their home games at Tad Smith Coliseum in Oxford, Mississippi as members of the Southeastern Conference. This season marked the first NCAA Tournament appearance in school history.
|-|-!colspan=6 style=|Regular season|-!colspan=12 style=| SEC tournament|-!colspan=12 style=| NCAA tournamentSource: [1]