| Mode: | Basketball |
| Year: | 1980–81 |
| Prev Year: | 1979–80 |
| Next Year: | 1981–82 |
| Team: | Northeastern Huskies |
| Short Conf: | ECAC-North |
| Record: | 24–6 |
| Conf Record: | 6–0 |
| Hc Year: | 9th |
| Ac1 Year: | 2nd |
| Champion: | ECAC North Regular-season champion ECAC North Conference tournament champion |
| Tourney Result: | Second round |
The 1980–81 Northeastern Huskies men's basketball team represented Northeastern University during the 1980–81 college basketball season. Led by head coach Jim Calhoun, the Huskies competed in the ECAC North Conference and played their home games at Matthews Arena. They finished the season 24–6 overall with a 6–0 mark in ECAC North play to win the regular season conference title. They followed the regular season by winning the ECAC North Conference tournament to earn a bid to the NCAA tournament as No. 11 seed in the West region. After upsetting Fresno State in the opening round, the Huskies were defeated in the second round by No. 3 seed Utah, 94–69.
|-!colspan=9 style=| Regular season
|-!colspan=9 style=| ECAC North tournament|-!colspan=9 style=| NCAA Tournament[3]