The 1980–81 Nationalliga A season was the 43rd season of the Nationalliga A, the top level of ice hockey in Switzerland. Eight teams participated in the league, and EHC Biel won the championship.
| Pl. | Team | GP | W | T | L | GF–GA | Pts | |
|---|---|---|---|---|---|---|---|---|
| 1. | EHC Biel | 28 | 21 | 2 | 5 | 158:113 | 44 | |
| 2. | EHC Arosa | 28 | 18 | 2 | 8 | 144:97 | 38 | |
| 3. | Fribourg-Gottéron | 28 | 13 | 5 | 10 | 111:106 | 31 | |
| 4. | EHC Kloten | 28 | 13 | 2 | 13 | 127:113 | 28 | |
| 5. | SC Bern | 28 | 13 | 1 | 14 | 107:132 | 27 | |
| 6. | SC Langnau | 28 | 12 | 2 | 14 | 120:120 | 26 | |
| 7. | HC Davos | 28 | 11 | 1 | 16 | 98:110 | 23 | |
| 8. | Lausanne HC | 28 | 1 | 5 | 22 | 85:159 | 7 |
| Pl. | Team | GP | W | T | L | GF–GA | Pts | |
|---|---|---|---|---|---|---|---|---|
| 1. | EHC Biel | 38 | 28 | 3 | 7 | 208:149 | 59 | |
| 2. | EHC Arosa | 38 | 25 | 2 | 11 | 212:138 | 52 | |
| 3. | SC Langnau | 38 | 17 | 3 | 18 | 163:158 | 37 | |
| 4. | Fribourg-Gottéron | 38 | 15 | 7 | 16 | 143:160 | 37 | |
| 5. | SC Bern | 38 | 17 | 2 | 19 | 147:184 | 36 | |
| 6. | EHC Kloten | 38 | 15 | 3 | 20 | 180:178 | 33 |
| Pl. | Team | GP | W | T | L | GF–GA | Pts | |
|---|---|---|---|---|---|---|---|---|
| 1. | HC Davos | 10 | 7 | 2 | 1 | 50:29 | 16 | |
| 2. | Zürcher SC | 10 | 7 | 1 | 2 | 44:33 | 15 | |
| 3. | HC Ambrì-Piotta | 10 | 5 | 0 | 5 | 54:50 | 10 | |
| 4. | Lausanne HC | 10 | 3 | 2 | 5 | 48:60 | 8 | |
| 5. | HC Sierre | 10 | 3 | 1 | 6 | 35:41 | 7 | |
| 6. | EHC Olten | 10 | 2 | 0 | 8 | 39:57 | 4 |