The 1980–81 Midland Football League was the 81st in the history of the Midland Football League, a football competition in England.
| Competition: | Midland Football League Premier Division |
| Season: | 1980–81 |
| Winners: | Boston |
| Relegated: | Kimberley Town |
| Matches: | 306 |
| Total Goals: | 922 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The Premier Division featured 17 clubs which competed in the previous season, along with one new club:
| Competition: | Midland Football League Division One |
| Season: | 1980–81 |
| Winners: | Borrowash Victoria |
| Matches: | 240 |
| Total Goals: | 744 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
Division One featured 15 clubs which competed in the previous season, along with one new club: