| Season: | 1980–81 |
| Competition: | Maltese Premier League |
| Winners: | Hibernians F.C. (5th title) |
| Relegated: | Birkirkara F.C. Marsa F.C. |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Hibernians F.C. |
| Continentalcup2: | European Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Floriana F.C. |
| Continentalcup3: | UEFA Cup |
| Continentalcup3 Qualifiers: | Sliema Wanderers F.C. |
| Matches: | 56 |
| Total Goals: | 151 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The 1980–81 Maltese Premier League was the 1st season of the Maltese Premier League, and the 66th season of top-tier football in Malta. It was contested by 8 teams, and Hibernians F.C. won the championship.