| Israel State Cup | |
| Year: | 1980–81 |
| Winners: | Bnei Yehuda (2nd Title) |
| Second: | Hapoel Tel Aviv |
| Prev Season: | 1979–80 |
| Next Season: | 1981–82 |
The 1980–81 Israel State Cup (Hebrew: גביע המדינה, Gvia HaMedina) was the 42nd season of Israel's nationwide football cup competition and the 27th after the Israeli Declaration of Independence.
The competition was won by Bnei Yehuda who have beaten Hapoel Tel Aviv 4–3 in penalty shoot-out, after 2–2 in the final.
Starting with this edition, if a match is drawn, a replay is to be played, drawn replays are to be settled with extra time and penalty shootouts. This does not include the final and the semi-final, which are still to be settled without replays.