| Competition: | Hong Kong First Division |
| Season: | 1980–81 |
| Winners: | Seiko |
| Relegated: | Police HKFC |
| Matches: | 110 |
| Total Goals: | 312 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The 1980–81 Hong Kong First Division League season was the 70th since its establishment.