The 1980–81 Hellenic Football League season was the 28th in the history of the Hellenic Football League, a football competition in England.
| Competition: | Hellenic Football League Premier Division |
| Season: | 1980–81 |
| Winners: | Newbury Town |
| Relegated: | Morris Motors Abingdon United |
| Matches: | 240 |
| Total Goals: | 748 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The Premier Division featured 14 clubs which competed in the division last season, along with two new clubs, promoted from Division One:
| Competition: | Hellenic Football League Division One |
| Season: | 1981–82 |
| Promoted: | Wantage Town Clanfield |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The Division One featured 12 clubs which competed in the division last season, along with 4 new clubs: