| 1980–81 Duleep Trophy | |
| Fromdate: | 7 December 1980 |
| Todate: | 23 February 1981 |
| Administrator: | BCCI |
| Cricket Format: | First-class cricket |
| Tournament Format: | Knockout |
| Champions: | West Zone |
| Count: | 10 |
| Participants: | 5 |
| Matches: | 4 |
| Most Runs: | Anshuman Gaekwad (WZ) (309)[1] |
| Most Wickets: | Barun Burman (EZ) (11)[2] |
| Previous Year: | 1979–80 |
| Previous Tournament: | 1978–79 Duleep Trophy |
| Next Year: | 1981–82 |
| Next Tournament: | 1981–82 Duleep Trophy |
The 1980–81 Duleep Trophy was the 20th season of the Duleep Trophy, a first-class cricket tournament contested by five zonal teams of India: Central Zone, East Zone, North Zone, South Zone and West Zone.
West Zone won the final against East Zone on first innings lead.