| Mode: | Basketball |
| Year: | 1980–81 |
| Team: | Duke Blue Devils |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Record: | 17–13 |
| Conf Record: | 6–8 |
| Hc Year: | 1st |
| Bowl Result: | Quarterfinals |
The 1980–81 Duke Blue Devils men's basketball team represented Duke University. The Blue Devils were coached by Mike Krzyzewski in his first year with the team. The club ranked fifth in the ACC. The team played its home games in the Cameron Indoor Stadium in Durham, North Carolina, and was a member of the Atlantic Coast Conference.
| Round | Pick | Player | NBA Club |
| 2 | 28 | Gene Banks | San Antonio Spurs |