| Mode: | Basketball |
| Year: | 1980–81 |
| Team: | Drexel Dragons |
| Conference: | East Coast Conference |
| Conference Link: | East Coast Conference (Division I) |
| Division: | East |
| Short Conf: | ECC |
| Record: | 14–13 |
| Conf Record: | 6–5 |
| Head Coach: | Eddie Burke |
| Hc Year: | 4th |
| Stadium: | Daskalakis Athletic Center |
The 1980–81 Drexel Dragons men's basketball team represented Drexel University during the 1980–81 NCAA Division I men's basketball season. The Dragons, led by 4th year head coach Eddie Burke, played their home games at the Daskalakis Athletic Center and were members of the East Coast Conference (ECC).
The team finished the season 14–13, and finished in 5th place in the ECC East in the regular season.
|-!colspan=9 style="background:#F8B800; color:#002663;"| Regular season|-|-!colspan=12 style="background:#FFC600; color:#07294D;"| ECC Tournament|-