| Competition: | Cypriot Third Division |
| Season: | 1980–81 |
| Winners: | Kentro Neotitas Maroniton (1st title) |
| Relegated: | Faros Acropoleos |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The 1980–81 Cypriot Third Division was the tenth season of the Cypriot third-level football league. Kentro Neotitas Maroniton won their 1st title.
Thirteen teams participated in the 1980–81 Cypriot Third Division. All teams played against each other twice, once at their home and once away. The team with the most points at the end of the season crowned champions. The first two teams were promoted to 1981–82 Cypriot Second Division. The last team was relegated to regional leagues.
Teams received two points for a win, one point for a draw and zero points for a loss.