| 1980–81 Cuban National Series | |
| League: | Cuban National Series |
| Sport: | Baseball |
| No Of Games: | 51 |
| No Of Teams: | 18 |
| Season: | Regular season |
| Season Champ Name: | Champion |
| Season Champs: | Vegueros (36–15) |
| Seasonslistnames: | SNB |
| Prevseason Link: | 1979–80 Cuban National Series |
| Prevseason Year: | 1979–80 |
| Nextseason Link: | 1981–82 Cuban National Series |
| Nextseason Year: | 1981–82 |
The 20th Cuban National Series saw Vegueros, from Pinar del Río Province, win its second title, with Villa Clara and Citricultores each finishing three games behind. The 18 teams of the league, each with a 51-game schedule, remained unchanged from the prior season.
| Team | W | L | Pct. | GB | |
|---|---|---|---|---|---|
| Vegueros (Pinar del Río) | 36 | 15 | .705 | - | |
| 33 | 18 | .647 | 3 | ||
| Citricultores (Matanzas) | 33 | 18 | .647 | 3 | |
| Industriales (Havana) | 32 | 19 | .627 | 4 | |
| Forestales (Pinar del Río) | 31 | 20 | .607 | 5 | |
| 30 | 21 | .588 | 6 | ||
| 28 | 23 | .540 | 8 | ||
| 26 | 25 | .509 | 10 | ||
| Henequeneros (Matanzas) | 25 | 26 | .490 | 11 | |
| 25 | 26 | .490 | 11 | ||
| 24 | 27 | .470 | 12 | ||
| Metropolitanos (Havana) | 23 | 28 | .450 | 13 | |
| 23 | 28 | .450 | 13 | ||
| 22 | 29 | .431 | 14 | ||
| 20 | 31 | .392 | 16 | ||
| 19 | 32 | .372 | 17 | ||
| 18 | 33 | .352 | 18 | ||
| 11 | 40 | .215 | 25 |