| Mode: | women's basketball |
| Year: | 1980–81 |
| Team: | Clemson Tigers |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Aprank: | 20 |
| Record: | 23–8 |
| Conf Record: | 6–1 |
| Hc Year: | 5th |
| Champion: | ACC Regular Season Champion |
The 1980–81 Clemson Tigers women's basketball team represented Clemson University during the 1980–81 women's college basketball season. The Tigers were led by fifth year head coach Annie Tribble. The Tigers, members of the Atlantic Coast Conference, played their home games at Littlejohn Coliseum.