| Mode: | Basketball |
| Sex: | none |
| Year: | 1980–81 |
| Prev Year: | 1979–80 |
| Next Year: | 1981–82 |
| Team: | Chattanooga Mocs |
| Conference: | Southern Conference |
| Division: | South |
| Short Conf: | SoCon |
| Record: | 21–9 |
| Conf Record: | 11–5 |
| Hc Year: | 2nd |
| Champion: | SoCon regular season and tournament champions |
| Tourney Result: | First round |
The 1980–81 Chattanooga Mocs basketball team represented the University of Tennessee at Chattanooga as a member of the Southern Conference during the 1980–81 NCAA Division I men's basketball season. Their head coach was Murray Arnold and the team played their home games at Maclellan Gymnasium. The Mocs won the regular season and SoCon tournament titles, the latter earning the Mocs an automatic bid to the 1981 NCAA tournament. Participating in the Big Dance for the first time in program history, Chattanooga fell to No. 6 seed Maryland in the opening round.[1]
Source:[2]
|-!colspan=9 style=| Regular season|-!colspan=9 style=| SoCon tournament|-!colspan=9 style=| NCAA tournamentSource:[3]
See main article: 1980–81 NCAA Division I men's basketball rankings.