| Competition: | Albanian National Championship |
| Season: | 1980–81 |
| Winners: | Partizani 13th Albanian title |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Partizani |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Dinamo Tirana |
| Continentalcup3: | Cup Winners' Cup |
| Continentalcup3 Qualifiers: | None |
| Matches: | 182 |
| Total Goals: | 355 |
| League Topscorer: | Dashnor Bajaziti (12 goals) |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The 1980–81 Albanian National Championship was the 42nd season of the Albanian National Championship, the top professional league for association football clubs, since its establishment in 1930.
It was contested by 14 teams, and Partizani won the championship.
Note: "17 Nëntori" is Tirana, "Labinoti" is Elbasani, "Lokomotiva Durrës" is Teuta and "Traktori" is Lushnja.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Dashnor Bajaziti | Besa | 12 |
| 2 | Vasillaq Zëri | Dinamo Tirana | 10 |
| 3 | Roland Luçi | Vllaznia | 8 |
| Aleko Bregu | Dinamo Tirana | ||
| Musa Fagu | Partizani | ||
| 6 | Vladimir Skuro | Naftëtari | 7 |
| Agim Murati | Partizani | ||