| Competition: | 1.Lig |
| Season: | 1980–81 |
| Winners: | Trabzonspor 5th title |
| Relegated: | Çaykur Rizespor Mersin İdman Yurdu Orduspor |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Trabzonspor |
| Continentalcup2: | Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Ankaragücü |
| Continentalcup3: | UEFA Cup |
| Continentalcup3 Qualifiers: | Adanaspor |
| League Topscorer: | Bora Öztürk (15 goals) |
| Matches: | 240 |
| Total Goals: | 466 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
Statistics of Turkish First Football League in season 1980/1981.
It was contested by 16 teams, and Trabzonspor won the championship. 1981–82 European Cup Winners' Cup spot goes to Second League team Ankaragücü, who was also promoted and went back to 1. Lig at the end of the 1980/81 season.