| Mode: | Basketball |
| Year: | 1979–80 |
| Team: | Penn Quakers |
| Conference: | Ivy League |
| Short Conf: | Ivy |
| Record: | 17–12 |
| Conf Record: | 11–3 |
| Hc Year: | 3rd |
| Champion: | Ivy League champions |
| Tourney Result: | Second Round |
The 1979–80 Penn Quakers men's basketball team represented the University of Pennsylvania as a member of the Ivy League during the 1979–80 NCAA Division I men's basketball season. Led by head coach Bob Weinhauer, the Quakers played their home games at The Palestra in Philadelphia. A year after reaching the Final Four, Penn again finished as Ivy League champions by defeating co-champion Princeton in a play-in game to receive an automatic bid to the NCAA tournament. Playing as the No. 12 seed in the Mideast region, the Quakers defeated No. 5 seed Washington State in the opening round, before losing to No. 4 seed Duke in the second round.