The 1979–80 Midland Football Combination season was the 43rd in the history of Midland Football Combination, a football competition in England.
| Competition: | Midland Football Combination Division One |
| Season: | 1979–80 |
| Winners: | Bridgnorth Town |
| Relegated: | Northfield Town Studley Sporting |
| Matches: | 380 |
| Total Goals: | 1000 |
| Prevseason: | 1978–79 |
| Nextseason: | 1980–81 |
Division One featured 17 clubs which competed in the division last season along with three new clubs: