| Mode: | Basketball |
| Year: | 1979–80 |
| Team: | Louisville Cardinals |
| Conference: | Metro Conference |
| Short Conf: | Metro |
| Coachrank: | 4 |
| Aprank: | 2 |
| Record: | 33–3 |
| Conf Record: | 12–0 |
| Hc Year: | 9th |
| Asst Coach1: | Bill Olsen |
| Asst Coach3: | Jerry Jones |
| Stadium: | Freedom Hall |
| Champion: | NCAA tournament National Champions Metro Conference tournament champions Metro Conference champions |
| Bowl Result: | W 59-54 vs. UCLA |
The 1979–80 Louisville Cardinals men's basketball team represented the University of Louisville during the 1979–80 NCAA Division I men's basketball season, Louisville's 66th season of intercollegiate competition. The Cardinals competed in the Metro Conference and were coached by Denny Crum. The team played home games at Freedom Hall.
The team completed a 33–3 record and brought Louisville basketball their first NCAA national championship when they defeated UCLA 59–54, led by Darrell Griffith and his 23 points.
|-!colspan=12| Regular Season |-!colspan=9| 1980 Metro Conference tournament|-!colspan=9| 1980 NCAA Division I men's basketball tournament
See also: 1979–80 NCAA Division I men's basketball rankings.
| Year | Round | Pick | Player | NBA Club | |
| 1 | 2 | Darrell Griffith | Utah Jazz | ||
| 2 | 36 | Scooter McCray | Seattle SuperSonics | ||
| 1 | 3 | Rodney McCray | Houston Rockets | ||
| 2 | 35 | Derek Smith | Golden State Warriors |