| Election Name: | 1978 United States Senate election in Michigan |
| Country: | Michigan |
| Flag Image: | Flag of Michigan.svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1972 United States Senate election in Michigan |
| Previous Year: | 1972 |
| Next Election: | 1984 United States Senate election in Michigan |
| Next Year: | 1984 |
| Election Date: | November 7, 1978 |
| Image1: | CarlLevin--100thCongress--.png |
| Nominee1: | Carl Levin |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 1,484,193 |
| Percentage1: | 52.14% |
| Nominee2: | Robert P. Griffin |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 1,362,165 |
| Percentage2: | 47.85% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | Robert P. Griffin |
| Before Party: | Republican Party (United States) |
| After Election: | Carl Levin |
| After Party: | Democratic Party (United States) |
The 1978 United States Senate election in Michigan was held on November 7, 1978. Incumbent Republican U.S. Senator Robert P. Griffin ran for re-election to a third term, but was defeated by the Democratic candidate, Detroit City Council President Carl Levin.