| 1978 U.S. Women's Open | |
| Dates: | July 20–23, 1978 |
| Location: | Indianapolis, Indiana |
| Course: | Country Club of Indianapolis |
| Org: | USGA |
| Tour: | LPGA Tour |
| Par: | 71 |
| Yardage: | [1] |
| Field: | 150 players, 66 after cut |
| Cut: | 154 (+12) [2] |
| Purse: | $100,000 |
| Winners Share: | $15,000 |
| Champion: |  Hollis Stacy |
| Score: | 289 (+5) |
| Previous: | 1977 |
| Next: | 1979 |
The 1978 U.S. Women's Open was the 33rd U.S. Women's Open, held July 20–23 at Country Club of Indianapolis in Indianapolis, Indiana.
Defending champion Hollis Stacy won the second of her three U.S. Women's Open titles, one stroke ahead of runners-up JoAnne Carner and She sank a 5adj=onNaNadj=on putt for par on the 72nd green to secure the win,[3] the second of her four major titles.
Rookie sensation Nancy Lopez was a co-leader after two rounds,[2] [4] but a 79 on Saturday took her out of and she tied
Sunday, July 23, 1978
| Place | Player | Score | To par | Money ($) | |||
|---|---|---|---|---|---|---|---|
| 1 | Hollis Stacy | 70-75-72-72=289 | +5 | 15,000 | |||
| align=center rowspan=2 | T2 | JoAnne Carner | 73-72-73-72=290 | align=center rowspan=2 | +6 | align=center rowspan=2 | 7,000 |
 Sally Little | 75-75-75-65=290 | ||||||
| align=center rowspan=2 | T4 | Jane Blalock | 74-74-71-74=293 | align=center rowspan=2 | +9 | align=center rowspan=2 | 4,650 |
| Pam Higgins | 74-73-75-71=293 | ||||||
| align=center rowspan=3 | T6 | Donna Caponi Young | 68-78-73-75=294 | align=center rowspan=3 | +10 | align=center rowspan=3 | 3,260 |
| Donna White | 72-72-79-71=294 | ||||||
| Kathy Martin | 76-74-71-73=294 | ||||||
| align=center rowspan=3 | T9 | Nancy Lopez | 71-73-79-72=295 | align=center rowspan=3 | +11 | align=center rowspan=3 | $2,533 |
| Peggy Conley | 75-76-70-74=295 | ||||||
 Sandra Post | 78-73-74-70=295 |