| Year: | 1978 |
| Team: | Pittsburgh Panthers |
| Sport: | football |
| Conference: | Independent |
| Record: | 8–4 |
| Head Coach: | Jackie Sherrill |
| Hc Year: | 2nd |
| Off Coach: | Don Boyce |
| Oc Year: | 1st |
| Off Scheme: | Split backs |
| Def Coach: | Jimmy Johnson |
| Dc Year: | 2nd |
| Def Scheme: | 5–2 |
| Stadium: | Pitt Stadium |
| Bowl: | Tangerine Bowl |
| Bowl Result: | L 17–30 vs. NC State |
The 1978 Pittsburgh Panthers football team represented the University of Pittsburgh in the 1978 NCAA Division I-A football season. The Panthers competed in the 1978 Tangerine Bowl.
Coach Jackie Sherrill stated in the pre-season that he expected to have "another outstanding football team".
| Player | Position | Round | Pick | NFL club | |
| Wide receiver | 2 | 34 | Tampa Bay Buccaneers | ||
| Center | 5 | 131 | Detroit Lions | ||
| Defensive back | 7 | 190 | Los Angeles Rams | ||
| Linebacker | 11 | 296 | Philadelphia Eagles | ||
| Nose Tackle | 12 | 307 | Tampa Bay Buccaneers |