| Year: | 1978 |
| Team: | Ole Miss Rebels |
| Sport: | football |
| Conference: | Southeastern Conference |
| Short Conf: | SEC |
| Record: | 5–6 |
| Conf Record: | 2–4 |
| Head Coach: | Steve Sloan |
| Hc Year: | 1st |
| Off Coach: | John Cropp |
| Oc Year: | 1st |
| Def Coach: | George MacIntyre |
| Dc Year: | 1st |
| Captain: | Bobby Garner |
| Captain2: | Lawrence Johnson |
| Captain3: | Curtis Weathers |
| Stadium: | Hemingway Stadium Mississippi Veterans Memorial Stadium |
The 1978 Ole Miss Rebels football team represented the University of Mississippi (Ole Miss) during the 1978 NCAA Division I-A football season as a member of the Southeastern Conference (SEC). The team was led by head coach Steve Sloan, in his first year, and they played their home games at Hemingway Stadium in Oxford, Mississippi and Mississippi Memorial Stadium in Jackson, Mississippi. Some of the outstanding players on the team of that year were Bobby Garner, Leon Perry, Reginald Woullard, Roy Coleman, Freddie Williams, etc. They finished the season with a record of five wins and six losses (5–6, 2–4 SEC).