| Year: | 1978 |
| Team: | Oklahoma State Cowboys |
| Sport: | football |
| Conference: | Big Eight Conference |
| Short Conf: | Big 8 |
| Record: | 3–8 |
| Conf Record: | 3–4 |
| Head Coach: | Jim Stanley |
| Hc Year: | 6th |
| Stadium: | Lewis Field |
The 1978 Oklahoma State Cowboys football team represented Oklahoma State University as a member of the Big Eight Conference during the 1978 NCAA Division I-A football season. Led by Jim Stanley in his sixth and final season as head coach, the Cowboys compiled an overall record of 3–8 with a mark of 3–4 in conference play, tying for fifth place in the Big 8. Oklahoma State played home games at Lewis Field in Stillwater, Oklahoma
The 1979 NFL draft was held on May 3–4, 1979. The following Cowboys were selected.[2]
| 9 | 223 | Scott Burk | Cincinnati Bengals | ||
| 10 | 254 | Steve Stephens | Baltimore Colts |