| Year: | 1978 |
| Team: | Louisville Cardinals |
| Sport: | football |
| Conference: | Independent |
| Record: | 7–4 |
| Head Coach: | Vince Gibson |
| Hc Year: | 4th |
| Stadium: | Fairgrounds Stadium |
The 1978 Louisville Cardinals football team was an American football team that represented the University of Louisville as an independent during the 1978 NCAA Division I-A football season. In their fourth season under head coach Vince Gibson, the Cardinals compiled a 7–4 record and outscored opponents by a total of 319 to 202.[1]
The team's statistical leaders included Stu Stram with 929 passing yards, Nathan Poole with 1,394 rushing yards and 96 points scored, and Kenny Robinson with 534 receiving yards.[2]