The 1978–79 Midland Football Combination season was the 42nd in the history of Midland Football Combination, a football competition in England at tier 7 of the English football league system. Sutton Coldfield Town won the championship. Sutton Coldfield Town, Blakenall, and Malvern Town transferred to the West Midlands (Regional) League for the 1979-80 season.
| Competition: | Midland Football Combination Division One |
| Season: | 1978–79 |
| Winners: | Sutton Coldfield Town |
| Matches: | 380 |
| Total Goals: | 967 |
| Prevseason: | 1977–78 |
| Nextseason: | 1979–80 |
Division One featured 19 clubs which competed in the division in the previous season along with one new club, promoted from Division Two: