The 1974–75 Midland Football Combination season was the 38th in the history of Midland Football Combination, a football competition in England.
| Competition: | Midland Football Combination Division One |
| Season: | 1974–75 |
| Winners: | Highgate United |
| Relegated: | Walsall Wood |
| Matches: | 306 |
| Total Goals: | 868 |
| Prevseason: | 1973–74 |
| Nextseason: | 1975–76 |
Division One featured 17 clubs which competed in the division last season along with one new club: