| Election Name: | 1972 United States Senate election in West Virginia |
| After Election: | Jennings Randolph |
| Before Party: | Democratic Party (United States) |
| Before Election: | Jennings Randolph |
| U.S. Senator | |
| Percentage2: | 33.55% |
| Popular Vote2: | 245,531 |
| Party2: | Republican Party (United States) |
| Nominee2: | Louise Leonard |
| Percentage1: | 66.45% |
| Country: | West Virginia |
| Popular Vote1: | 486,310 |
| Party1: | Democratic Party (United States) |
| Nominee1: | Jennings Randolph |
| Election Date: | November 7, 1972 |
| Next Year: | 1978 |
| Next Election: | 1978 United States Senate election in West Virginia |
| Previous Year: | 1966 |
| Previous Election: | 1966 United States Senate election in West Virginia |
| Ongoing: | no |
| Type: | presidential |
| Map Size: | 245px |
| After Party: | Democratic Party (United States) |
The 1972 United States Senate election in West Virginia took place on November 7, 1972. West Virginia was one of fifteen states alongside Alabama, Arkansas, Colorado, Delaware, Georgia, Iowa, Louisiana, Maine, Minnesota, Mississippi, Montana, New Hampshire, Rhode Island and South Dakota that were won by Republican President Richard Nixon in 1972 that elected a Democrat to the United States Senate. Incumbent Democratic U.S. Senator Jennings Randolph was re-elected to a fourth term and a third full term defeating Louise Leonard in a landslide. This was the only United States Senate election in West Virginia that Jennings Randolph had won by more than 60% of the vote.