| Election Name: | 1972 United States Senate election in Virginia |
| Country: | Virginia |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1966 United States Senate election in Virginia |
| Previous Year: | 1966 |
| Next Election: | 1978 United States Senate election in Virginia |
| Next Year: | 1978 |
| Election Date: | November 7, 1972 |
| Turnout: | 44.7%[1] |
| Nominee1: | William L. Scott |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 718,337 |
| Percentage1: | 51.45% |
| Nominee2: | William Spong, Jr. |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 643,963 |
| Percentage2: | 46.12% |
| Map Size: | 301px |
| U.S. Senator | |
| Before Election: | William B. Spong, Jr. |
| Before Party: | Democratic Party (United States) |
| After Election: | William Lloyd Scott |
| After Party: | Republican Party (United States) |
The 1972 United States Senate election in Virginia was held on November 7, 1972. Republican U.S. Representative William L. Scott defeated incumbent Democratic Senator William Spong Jr. Scott was the first Republican U.S. Senator from Virginia to be elected in over a century, as the most recent Republican Senator was John F. Lewis, who had served during the Reconstruction era until 1875.
He was the first Republican to ever win this seat, and the first non-Democrat since 1889. This is the last time a candidate not named Warner won Virginia's Class 2 Senate seat.