| Election Name: | 1972 United States Senate election in Mississippi |
| Country: | Mississippi |
| Flag Image: | Flag of Mississippi (1894-1996).svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1966 United States Senate election in Mississippi |
| Previous Year: | 1966 |
| Election Date: | November 7, 1972 |
| Next Election: | 1978 United States Senate election in Mississippi |
| Next Year: | 1978 |
| Image1: | File:James O Eastland.jpg |
| Nominee1: | James Eastland |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 375,102 |
| Percentage1: | 58.09% |
| Map Size: | 255px |
| U.S. Senator | |
| Before Election: | James Eastland |
| Before Party: | Democratic Party (United States) |
| After Election: | James Eastland |
| After Party: | Democratic Party (United States) |
| Nominee2: | Gil Carmichael |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 249,779 |
| Percentage2: | 38.68% |
The 1972 United States Senate election in Mississippi was held on November 7, 1972. Incumbent Democratic U.S. Senator James Eastland won re-election to his sixth term. To date, this was the last time that the Democrats won the Class 2 Senate seat in Mississippi. Mississippi was one of fifteen states alongside Alabama, Arkansas, Colorado, Delaware, Georgia, Iowa, Louisiana, Maine, Minnesota, Montana, New Hampshire, Rhode Island, South Dakota and West Virginia that were won by Republican President Richard Nixon in 1972 that elected Democrats to the United States Senate.
Meredith ran as an anti-Nixon candidate, while Carmichael supported President Nixon's re-election.