| Election Name: | 1972 United States Senate election in Michigan |
| Country: | Michigan |
| Flag Image: | Flag of Michigan.svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1966 United States Senate election in Michigan |
| Previous Year: | 1966 |
| Next Election: | 1978 United States Senate election in Michigan |
| Next Year: | 1978 |
| Election Date: | November 7, 1972 |
| Image1: | File:Robert Paul Griffin.jpg |
| Nominee1: | Robert P. Griffin |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,781,065 |
| Percentage1: | 52.28% |
| Nominee2: | Frank J. Kelley |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 1,577,178 |
| Percentage2: | 46.29% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | Robert P. Griffin |
| Before Party: | Republican Party (United States) |
| After Election: | Robert P. Griffin |
| After Party: | Republican Party (United States) |
The 1972 United States Senate election in Michigan was held on November 7, 1972. Incumbent Republican U.S. Senator and Senate Minority Whip Robert P. Griffin ran for re-election to a second term, won reelection defeating the Democratic candidate, and Michigan Attorney General Frank J. Kelley by 6%. Despite President Richard Nixon’s landslide victory in Michigan and the rest of the country, Griffin’s margin of victory decreased from the previous election.
As of, this was the last time that the Republicans have won Michigan’s Class 2 Senate seat, as well as the last time that a member of the party has been re-elected to either of the state’s Senate seats.