The 1972 Titleholders Championship was contested from May 26–29 at Pine Needles Lodge and Golf Club in Southern Pines, North Carolina. It was the 28th and final edition of the Titleholders Championship, following a six-year hiatus. It was the only edition not played at the Augusta Country Club.
This event was won by Sandra Palmer.
| Place | Player | Score | To par | Money ($) | |||
|---|---|---|---|---|---|---|---|
| 1 |  Sandra Palmer | 71-68-72-72=283 | −1 | 3,000 | |||
| align=center rowspan=2 | T2 | Judy Rankin | 73-74-70-76=293 | align=center rowspan=2 | +9 | align=right rowspan=2 | 2,032 |
| Mickey Wright | 73-73-70-77=293 | ||||||
| align=center rowspan=2 | T4 | Marlene Hagge | 72-77-72-73=294 | align=center rowspan=2 | +10 | align=right rowspan=2 | 1,337 |
| Kathy Whitworth | 78-69-77-70=294 | ||||||
| 6 | Marilynn Smith | 72-70-74-80=296 | +12 | 1,000 | |||
| align=center rowspan=2 | T7 | Jane Blalock | 72-76-76-74=298 | align=center rowspan=2 | +14 | align=right rowspan=2 | 800 |
| Carol Mann | 78-72-74-74=298 | ||||||
| 9 | Clifford Ann Creed | 79-72-73-76=300 | +16 | 655 | |||
| align=center rowspan=2 | T10 | JoAnne Carner | 78-76-72-76=302 | align=center rowspan=2 | +18 | align=right rowspan=2 | 555 |
| Peggy Wilson | 74-75-74-79=302 |