The 1972–73 Midland Football Combination season was the 36th in the history of Midland Football Combination, a football competition in England.
| Competition: | Midland Football Combination Division One |
| Season: | 1972–73 |
| Winners: | Highgate United |
| Matches: | 306 |
| Total Goals: | 918 |
| Prevseason: | 1971–72 |
| Nextseason: | 1973–74 |
Division One featured 17 clubs which competed in the division last season along with one new club: