The 1971–72 Midland Football Combination season was the 35th in the history of Midland Football Combination, a football competition in England.
| Competition: | Midland Football Combination Division One |
| Season: | 1971–72 |
| Winners: | Alvechurch |
| Relegated: | Smethwick Highfield |
| Matches: | 306 |
| Total Goals: | 950 |
| Prevseason: | 1970–71 |
| Nextseason: | 1972–73 |
Division One featured 17 clubs which competed in the division last season along with one new club: