| Competition: | Campeonato Profesional |
| Season: | 1969 |
| Winners: | Deportivo Cali (3rd title) |
| Continentalcup1: | Copa Libertadores |
| Continentalcup1 Qualifiers: | Deportivo Cali América de Cali |
| League Topscorer: | Hugo Horacio Lóndero (24 goals) |
| Prevseason: | 1968 |
| Nextseason: | 1970 |
The 1969 Campeonato Profesional was the 21st season of Colombia's top-flight football league. 14 teams competed against one another. Deportivo Cali won the Torneo Apertura, while Millonarios won the Torneo Clausura. Cali went on to win their third league title in the triangular final which was held in January 1970, while América de Cali earned the right to enter the 1970 Copa Libertadores instead of Millonarios. Hugo Horacio Lóndero, playing for América de Cali, was the topscorer with 24 goals.[1]
Note: Millonarios took all their five penalties first, and Cali given the chance to match them. However, Cali missed their first penalty and the game ended there, as Millonarios had scored all of theirs.
| Rank | Name | Club | Goals | ||
|---|---|---|---|---|---|
| align=center | 1 |  Hugo Horacio Lóndero | América de Cali | 24 | |
| 2 | Walter Sossa | Santa Fe | 23 | ||
| Pedro Prospitti | |||||
| align=center | 4 | Juan Carlos Lallana | Deportivo Cali | 21 | |
| align=center | 5 | Eduardo Curia | América de Cali | align=center | 20 |
| 6 |  Alfredo Arango (footballer) | Unión Magdalena | 18 | ||
| Edison Angulo | Deportivo Pereira | ||||
| Orlando Mesa | Deportes Quindío | ||||
| 9 |  Airton Dos Santos | Junior | 16 | ||
| Gustavo Santa | Atlético Nacional | ||||
Source: RSSSF.com Colombia 1969