| Election Name: | 1968 United States Senate election in Pennsylvania |
| Country: | Pennsylvania |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1962 United States Senate election in Pennsylvania |
| Previous Year: | 1962 |
| Next Election: | 1974 United States Senate election in Pennsylvania |
| Next Year: | 1974 |
| Election Date: | November 5, 1968 |
| Image1: | Sen Richard Schweiker.jpg |
| Nominee1: | Richard Schweiker |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 2,399,762 |
| Percentage1: | 51.90% |
| Nominee2: | Joseph S. Clark Jr. |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 2,117,662 |
| Percentage2: | 45.80% |
| Map Size: | 260px |
| U.S. Senator | |
| Before Election: | Joseph S. Clark, Jr. |
| Before Party: | Democratic Party (United States) |
| After Election: | Richard Schweiker |
| After Party: | Republican Party (United States) |
The 1968 United States Senate election in Pennsylvania was held on November 5, 1968. Incumbent Democratic U.S. Senator Joseph S. Clark Jr. sought re-election to a third term but was defeated by Republican U.S. Representative Richard Schweiker. This election marked the last time that an incumbent Senator lost re-election to this seat.