| Election Name: | 1968 United States Senate election in Oklahoma |
| Country: | Oklahoma |
| Flag Year: | 1941 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1962 United States Senate election in Oklahoma |
| Previous Year: | 1962 |
| Next Election: | 1974 United States Senate election in Oklahoma |
| Next Year: | 1974 |
| Election Date: | November 3, 1968 |
| Image1: | BellmonHL.jpg |
| Nominee1: | Henry Bellmon |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 470,120 |
| Percentage1: | 51.71% |
| Nominee2: | Mike Monroney |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 419,658 |
| Percentage2: | 46.16% |
| U.S. Senator | |
| Before Election: | Mike Monroney |
| Before Party: | Democratic Party (United States) |
| After Election: | Henry Bellmon |
| After Party: | Republican Party (United States) |
The 1968 United States Senate election in Oklahoma was held November 3, 1968. Incumbent Democratic U.S. Senator Mike Monroney was running for re-election to a fourth term, but was defeated by Republican Henry Bellmon. This is the last time that a Senator from Oklahoma lost re-election.
This election was the first time since 1942 that a Republican won a United States Senate election in Oklahoma and the first time since 1920 that a Republican won a United States Senate election in Oklahoma for this seat.