| Election Name: | 1968 United States Senate election in Ohio |
| Country: | Ohio |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1962 United States Senate election in Ohio |
| Previous Year: | 1962 |
| Next Election: | 1974 United States Senate election in Ohio |
| Next Year: | 1974 |
| Election Date: | November 5, 1968 |
| Image1: | William B. Saxbe (1).jpg |
| Nominee1: | William B. Saxbe |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,928,964 |
| Percentage1: | 51.53% |
| Nominee2: | John J. Gilligan |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 1,814,152 |
| Percentage2: | 48.47% |
| Map Size: | 210px |
| U.S. Senator | |
| Before Election: | Frank J. Lausche |
| Before Party: | Democratic Party (United States) |
| After Election: | William Saxbe |
| After Party: | Republican Party (United States) |
The 1968 United States Senate election in Ohio took place on November 5, 1968. Incumbent Senator Frank Lausche ran for re-election to a third term, but lost the Democratic primary to former U.S. Representative John J. Gilligan. Before losing the primary to the more solidly liberal Gilligan, Lausche had one of the most conservative voting record among Senate Democrats outside of The South, leaving the Democratic Party very disappointed. In the general election, Gilligan lost to Republican Ohio Attorney General William Saxbe in a close race. Saxbe's victory increased the number of Senate Republicans in the 91st Congress. He would serve 5 years in the Senate before being nominated by President Richard Nixon to be U.S Attorney General, he resigned the seat after being confirmed. Gilligan, who in January 1974 was serving as the Governor of Ohio, named Saxbe's successor.