| Dates: | 27 April 1968 – 11 January 1969 |
| Winners: | Santiago Wanderers (2nd title) |
| Relegated: | Unión San Felipe |
| Matches: | 325 |
| Total Goals: | 1018 |
| Continentalcup1: | 1969 Copa Libertadores |
| Continentalcup1 Qualifiers: | Santiago Wanderers Universidad Católica (Play-off Winners) |
| League Topscorer: | Eladio Zárate (32 goals) |
| Highest Attendance: | 70,481 |
| Attendance: | 3,697,921 |
| Average Attendance: | 11,378 |
| Prevseason: | 1967 |
| Nextseason: | 1969 |
The 1968 Campeonato Nacional de Futbol Profesional was Chilean first tier’s 36th season. Santiago Wanderers were the champions, winning its second title.
Universidad Católica also qualified for the 1969 Copa Libertadores due to better goal difference in the Final stage
| Rank | Name | Club | Goals | ||
|---|---|---|---|---|---|
| align=center | 1 | Eladio Zárate | Unión Española | 32 | |
| align=center | 2 | Osvaldo Castro | Unión La Calera | 31 | |
| align=center | 3 | Carlos Reinoso | Audax Italiano | 21 |