| Year: | 1968 |
| Team: | Prairie View A&M Panthers |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Short Conf: | SWAC |
| Record: | 4–6 |
| Conf Record: | 2–5 |
| Head Coach: | Hoover J. Wright |
| Hc Year: | 3rd |
| Stadium: | Edward L. Blackshear Field |
The 1968 Prairie View A&M Panthers football team represented Prairie View A&M University as a member of the Southwestern Athletic Conference (SWAC) during the 1968 NCAA College Division football season. They were led by third-year head coach Hoover J. Wright and played their home games at Edward L. Blackshear Field in Prairie View, Texas. Prairie View A&M finished the season with an overall record of 4–6 and a mark of 2–5 in conference play, placing sixth in the SWAC.