| Score: | 6–3, 6–1, 2–6, 6–2 |
| Draw: | 135 (8) |
| Seeds: | 16 |
| Before Name: | French Championships – Men's singles |
| After Name: | French Open – Men's singles |
| Type: | grand slam |
See main article: 1968 French Open.
Ken Rosewall defeated Rod Laver in the final, 6–3, 6–1, 2–6, 6–2 to win the men's singles tennis title at the 1968 French Open. It was Rosewall's second French title and fifth Grand Slam tournament title overall. The tournament was the first major of the Open Era, in which professionals were allowed to compete against amateurs. Rosewall and Laver, who had not appeared in a Grand Slam tournament since 1956 and 1962 respectively, were among those no longer barred from entering.
Roy Emerson was the defending champion, but lost in the quarterfinals to Pancho Gonzales.
Missing from the tournament were WCT's "Handsome Eight" and top amateurs Manuel Santana, Arthur Ashe, Clark Graebner and Tom Okker.
It was future champion and future world No. 1 Ilie Năstase's first major appearance.
See also: 1 and 8. 
Rod Laver (final)
See also: 2 and 1. Ken Rosewall (champion)
See also: 3 and 3. 
Andrés Gimeno (semifinals)
See also: 4 and 6. Roy Emerson (quarterfinals)
See also: 5 and 5. 
Pancho Gonzales (semifinals)
See also: 6 and 4. Fred Stolle (second round)
See also: 7 and 2. Lew Hoad (first round, withdrew)
See also: 8 and 7. Bob Hewitt (third round)
See also: 9 and 7. Ion Țiriac (quarterfinals)
See also: 10 and 2. Wilhelm Bungert (first round, withdrew)
See also: 11 and 4. 
Nicola Pietrangeli (first round, withdrew)
See also: 12 and 5. 
István Gulyás (fourth round)
See also: 13 and 6. Cliff Richey (fourth round)
See also: 14 and 3. Ray Ruffels (fourth round)
See also: 15 and 1. Jan Kodeš (first round, withdrew)
See also: 16 and 8. Alex Metreveli (first round, withdrew)
See main article: 1968 French Open – Men's singles qualifying.