| National Challenge Cup | |
| Year: | 1966 |
| Country: |  United States |
| Date: | --> |
| Defending Champions: | New York Ukrainians |
| Winners: | Philadelphia Ukrainian Nationals |
| Count: | 4 |
| Second: | Orange County Soccer Club |
| Semifinal1: | --> |
| Semifinal2: | --> |
| Continental Cup Title: | 1967 CONCACAF Champions' Cup |
| Continental Cup Qualifiers: | Philadelphia Ukrainian Nationals |
| Prev Season: | 1965 |
| Next Season: | 1967 |
The 1966 National Challenge Cup was the 53rd edition of the USSFA's annual open soccer championship. The Philadelphia Ukrainians defeated the Orange County Soccer Club to win.