| Sport: | soccer |
| Year: | 1966 |
| Team: | San Francisco Dons |
| Image Alt: | 1966 USF Dons Men's Championship Soccer Team |
| Conference: | Independent |
| Record: | 11–0–1 |
| Conf Record: | N/A |
| Head Coach: | Stephen Negoesco |
| Hc Year: | 5th |
| Tourney: | NCAA Tournament |
| Tourney Result: | W 5–2 vs. Long Island |
| Champion: | National Champions |
| Prev Year: | 1965 |
| Next Year: | 1967 |
The 1966 San Francisco Dons men's soccer team represented the University of San Francisco during the 1966 NCAA Division I Men's Soccer Season. The Dons won their first NCAA Soccer Championship title this season, defeating Long Island in the championship. It was the 23rd season the Dons fielded a men's varsity soccer team.
The 1966 team was coached by Stephen Negoesco for his fifth season at the helm. Negoesco guided the Dons to an 11-0-1 record. On the third of December, the USF soccer team played through mud to beat the Long Island University team with a 5–2 victory and the NCAA championship.
|-!colspan=6 style=""| Preseason|-|-!colspan=6 style=""| Regular season|-|-!colspan=6 style=""| NCAA Tournament|-|-