| Season: | 1966 |
| Manager: |  Aymoré Moreira |
| Mgrtitle: | Manager |
| Chairman: | Laudo Natel |
| Chrtitle: | Chairman |
| League: | Torneio Rio-São Paulo |
| League Result: | Runners-up |
| Cup1: | Campeonato Paulista |
| Cup1 Result: | 5th |
| Prevseason: | 1965 |
| Nextseason: | 1967 |
The 1966 football season was São Paulo's 37th season since club's existence.
| Games played | 52 (9 Torneio Rio-São Paulo, 28 Campeonato Paulista, 15 Friendly match) |
| Games won | 23 (5 Torneio Rio-São Paulo, 12 Campeonato Paulista, 6 Friendly match) |
| Games drawn | 15 (0 Torneio Rio-São Paulo, 10 Campeonato Paulista, 5 Friendly match) |
| Games lost | 14 (4 Torneio Rio-São Paulo, 6 Campeonato Paulista, 4 Friendly match) |
| Goals scored | 93 |
| Goals conceded | 66 |
| Goal difference | +27 |
| Best result | 5–0 (A) v Ituveravense - Friendly match - 1966.04.21 |
| Worst result | 0–3 (A) v Palmeiras - Campeonato Paulista - 1966.12.15 |
| Most appearances | |
| Top scorer | |