| Year: | 1965 |
| Team: | Southern Illinois Salukis |
| Sport: | football |
| Conference: | Independent |
| Record: | 2–8 |
| Head Coach: | Don Shroyer |
| Hc Year: | 2nd |
| Stadium: | McAndrew Stadium |
The 1965 Southern Illinois Salukis football team was an American football team that represented Southern Illinois University (now known as Southern Illinois University Carbondale) as an independent during the 1965 NCAA College Division football season. Under second-year head coach Don Shroyer, the team compiled a 2–8 record.[1] The team played its home games at McAndrew Stadium in Carbondale, Illinois.