| 1965 Senior League World Series | |
| Start Date: | August 19 |
| End Date: | 21, 1965 |
| Champion: | -->  Monterrey, Mexico |
| Runner-Up1: | --> El Campo, Texas |
| Runner-Up2: | --> |
| Previous: | 1964 |
| Next: | 1966 |
The 1965 Senior League World Series took place from August 19–21 in Des Moines, Iowa, United States. Monterrey, Mexico defeated El Campo, Texas in the championship game. This was the first SLWS held in Des Moines.
This year marked the first appearance by a Canadian team.
| United States | International |
|---|---|
| Norwich, Connecticut East |  Stoney Creek, OntarioCanada |
| Merrillville, Indiana North | Monterrey, Mexico Del Norte Latin America |
| El Campo, Texas South | |
| San Jose, California West Branham Hills West |