| Competition: | Luxembourg National Division |
| Season: | 1965–66 |
| Winners: | FC Aris Bonnevoie (2nd title) |
| Matches: | 132 |
| Total Goals: | 514 |
| Highest Scoring: | Alliance Dudelange 5–5 Stade Dudelange |
| Prevseason: | 1964–65 |
| Nextseason: | 1966–67 |
The 1965–66 Luxembourg National Division was the 52nd season of top level association football in Luxembourg.
It was performed in 12 teams, and FC Aris Bonnevoie won the championship.