| Competition: | Primera División |
| Season: | 1965–66 |
| Winners: | Atlético Madrid (5th title) |
| Relegated: | Málaga Mallorca Real Betis |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Atlético Madrid Real Madrid (as title holders) |
| Continentalcup2: | Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Zaragoza |
| League Topscorer: | Vavá II (19 goals) |
| Biggest Home Win: | Zaragoza 6–1 Elche Barcelona 5–0 Sabadell |
| Biggest Away Win: | Real Betis 0–4 Córdoba |
| Highest Scoring: | Valencia 6–3 Real Betis |
| Matches: | 240 |
| Total Goals: | 609 |
| Prevseason: | 1964–65 |
| Nextseason: | 1966–67 |
The 1965–66 La Liga was the 35th season of La Liga since its establishment. The season started on September 4, 1965, and finished on April 3, 1966.
| Team | Home city | Stadium | |
|---|---|---|---|
| Barcelona | Nou Camp | ||
| El Arcángel | |||
| Sarrià | |||
| Insular | |||
| La Rosaleda | |||
| Lluís Sitjar | |||
| Pontevedra | Pasarón | ||
| Real Betis | Benito Villamarín | ||
| Real Madrid | |||
| Sabadell | Creu Alta | ||
| Seville | |||
| Valencia | |||
| Zaragoza | La Romareda |
|}
| Goalscorers | Goal | Team | |
|---|---|---|---|
 Luciano Sánchez "Vavá II" | 19 | Elche CF | |
| Luis Aragonés | 18 | Atlético Madrid | |
| Nemesio Martín | 14 | Pontevedra CF | |
| Javier Ormaza Garay | 14 | Atlético Bilbao | |
 Danny Bergara | 13 | RCD Mallorca |